Electrocardiographic abnormalities and their association with some serum biomarkers in lambs with foot and mouth disease

Nikvand, Ali Abbas; Jalali, Missagh; Ghadrdan Mashhadi, Alireza; Nouri, Mohammad; Hassanpour Amirabadi, Soroush

doi:10.22055/ijrhr.2020.32795.1030

Electrocardiographic abnormalities and their association with some serum biomarkers in lambs with foot and mouth disease

Document Type : Research Paper

Authors

¹ Department of Clinical Sciences, Faculty of veterinary medicine, Shahid Chamran university of Ahvaz, Ahvaz- Iran

² Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz

³ Department of clinical sciences, Faculty of veterinary medicine, Shahid chamran University of Ahvaz, Ahvaz, Iran.

⁴ Department of clinical sciences, Faculty of veterinary medicine, Shahid Chamran University

10.22055/ijrhr.2020.32795.1030

Abstract

Little attention has been paid to the aspects of cardiac injury-related foot and mouth disease (FMD) in young animals. So, this research was conducted to evaluate the serum biomarkers and electrocardiographic (ECG) evidence of myocardial injury in the infected lambs with FMD. During an outbreak, 33 lambs with FMD and 11 healthy lambs were randomly enrolled. After blood sampling, ECGs were taken from 24 out of 33 infected lambs. Serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) activities were measured in the patient and control group. Interpretation of ECG showed abnormalities such as sinus tachycardia, premature ventricular complex (PVC) and ventricular tachycardia (VT) in 9, 5 and 6 scik lambs, respectively. The patients had significant greater serum CK-MB activity (170 ± 36 IU/L) compared to control (51.4 ± 4.7), (P<0.01). The lambs with VT had the highest serum CK-MB (546.5± 192 IU/L) and LDH (2813± 523 IU/L) activities compare to the affected lambs with the other dysrhythmias (P<0.01). It seems that CK-MB has a reliable value for detecting cardiac injury in sheep. Due to the highest CK-MB level in the lambs with VT, it seems VT is associated with highest cardiac lesion compared to the others arrhythmias in FMD lambs.

Keywords

References

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