Seasonal variations of tissues and serum copper concentrations in chronic copper poisoned goats

Document Type : Research Paper

Authors

1 Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2 Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, P.O.Box: 71345-1731, Iran.

3 Department of Comparative Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

4 Department of Environmental Geology, School of Science, Shiraz University, Shiraz, Iran

10.22055/ijrhr.2019.29498.1024

Abstract

Primary chronic forms of copper poisoning have been reported to occur in goats around the copper industries in Kerman province. The survey was carried out from autumn 2015 to the end of summer 2016, in Kerman province, Iran. Based on clinical signs, confirmed by necropsy and copper concentration of serum and different tissues, ten live chronic copper poisoned (CCP) goats were used in the study in each season. Blood samples were then taken. Samples from hair, liver, lung, kidney, heart and spleen were collected and copper was measured by Atomic Absorption Spectrophotometery. The highest levels of copper in lung, heart, liver, kidney and hair were observed in winter. Spleen had the highest concentration of copper in the summer. The lowest concentration of copper in serum, kidney, liver, heart, lung and hair was detected in spring. The lowest level of copper in the spleen was seen in winter. In spring, copper contents of liver had significant and positive relationships with copper level of lung, heart and spleen (p<0.05). Significant correlations were found between various tissues in different seasons. The highest and lowest serum concentration of molybdenum was observed in spring and winter, respectively (p<0.05). Serum ceruluplasmin significantly decreased in all seasons (p<0.05). In conclusion, the results of the current research showed that the level of copper in CCP goats is season-dependent. Significant correlations were also observed between different tissues in certain seasons in CCP goats. Ceruloplasmin decreased in CCP goats as a result of liver damage.

Keywords

References

References

Adam, S.E.I. & Wasfi, I.A. (1977). Chronic copper toxicity in Nubian goats. J. Comp.Pathol. 87, 623– 627.
Agency for Toxic Substances and Disease Registry (ATSDR). (2004). Toxicological Profile for Copper.
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. 
Bhavani, P. & Sujatha, B. Impact of toxic metals leading to environmental pollution. (2014). J.
Chem. Pharm. Sci. 3, 70-72.
Brekken, A. & Steinnes, E. (2004). Seasonal concentrations of cadmium and zinc in native pasture plants: consequences for grazing animals. Sci Total Environ. 326 (13), 181-195.
Carmalt, J., Baptiste, K. & Blakley, B. (2001). Suspect copper toxicity in an alpaca.  Can. Vet. J. 42, 554556.
Comar, C.L., Davis, G.K. & Singer, L. (1948). The fate of radioactive copper administered to the bovine.J. Biol. Chem.174, 3, 905-914.
Chairman, T.J., Bowland, J.P. & Deyoe, C.W. (1975). Nutrient
Requirements of Sheep. National Academy Press. Washington DC,
5th ed. 10-12. Church, D.C.  & Pond, W.G. Basic Animal Nutrition and Feeding. (1988). John Wiley and Sons, New York. 3rd ed. PP: 196-199. 
Dick, AT. (1969). The coppermolybdenum complex in ruminal nutrition. Outlook. Agr. 6, 1, 14-28.   Elshkaki, A., Graedel, T., Ciacci, L. & Reck, B. (2016). Copper demand, supply, and associated energy use to 2050. Global. Environ. Chang, 39, 305–315.
Falah, S., Fartusie, A.L. & Mohssan, SN. (2017). Essential Trace Elements and Their Vital Roles in Human Body. Indian. J. Adv.
Chem. Sci. 5, 3, 127-136.
Fox, P.L., Mazumder, B. Ehrenwald, E. & Mukhopadhyay, C.K. (2000). Ceruloplasmin and cardiovascular disease. Free. Radic. Biol. Med. 28, 12, 1735-44.
Hart, S. (2008). Meat Goat Nutrition. In proceedings Annual Goat Field Day Langston, USA. 23rd ed. PP:
58-83.
Hefnawy, A.E. & El-khaiat, H.M. (2015). Copper and animal health: Importance, maternal fetal, immunity and DNA relationship, deficiency and toxicity. International Journal for Agro Veterinary and Medical Sciences, 9, 5, 195-21.
Hopkins, A., Adamson, A.H. &
Bowling, P.J. (1994). Response of permanent and reseeded grassland to fertilizer nitrogen. 2. Effects on concentrations of Ca, Mg, Na, K, S, P, Mn, Zn, Cu, Co and Mo in herbage at a range of sites. Grass.
Forage. Sci. 49, 9–20.
Howard, J., Laura, B. & Neil, M.P. (2014). Copper toxicity in a New Zealand dairy herd. Ir. Vet. J. 67, 1, 20.
José Fernando, V.A. & Rolando, R.R. (2011). Effect of season on serum copper and zinc concentrations in crossbred goats having different reproductive status under semiarid rangeland conditions in Southern Mexico State. Trop. Subtrop. Agro ecosyst. 14, 1, 331-335.
Khan, Z., Hussain, A. & Ashraf, M. (2006). Determination of copper status of grazing sheep: seasonal influence and Ermidou-Pollet. Iran. J. Vet. Res. 7, 4, 17.
Kim, N.D. & Fergusson, J.E. (1994). Seasonal variations in the concentrations of cadmium, copper, lead and zinc in the leaves of the horse chestnut (Aesculus hippocastanum L.). Environ. Pollut. 86, 89-97.
Kimberling, C.V., Jensen & Swift's Disease of Sheep. (1988). Philadelphia, USA, Lea and
Febiger. 3rd  ed. PP: 372-374.
Kurek, L., Olech, M., Lutnicki, K., Brodzki, P., Golynski, M., Riha, T. & Abramowicz, B. (2017). Longterm subclinical copper deficiency and its influence on functions of parenchymal organs and the serum macro-element deficiency in dairy cows. J. Elem. 22, 1415-1425.
Mathenge, J.M. (1978). Experimental chronic copper poisoning in sheep. A Thesis Presented to the Faculty of the Graduate School of Cornell University in Partial Fulfillment for the Degree of Doctor of
Philosophy.
Marcilese, N.A., Ammerman, C.B.,
Valsecchi, R.M., Dunavant, B.G. & Davis, G.K. (1969). Effect of Dietary Molybdenum and Sulfate upon Copper Metabolism in Sheep.
Nutr. J. 99, 2, 177-183.
Martin, M.H. & Coughtrey, P.J. (1982). Biological monitoring of heavy metal pollution. Netherlands, Springer Netherlands. 1st ed. PP:
60-150. 
Merwe, DVD. & Jones, M. (2012). Sheep and Goat Medicine. Elsevier Saunders. 2nd ed. PP: 100-103.
Mecitoglu, Z., Topal, O., Kacar, Y. & Batmaz, H. (2017). Comparing the effects of treatment with ammonium molybdate versus ammonium molybdate and phenoxy-2-methyl-2-propionic acid on liver functions in natural copper poisoning of sheep.  
Small. Ruminant. Res. 150, 93–96.
Minson D.J. (1990). Forages in Ruminant Nutrition. San Diego, USA, 1st  ed. PP: 208–229.
Morgan, P., Grace, N. & Lilley, D. (2014). Using sodium molybdate to treat chronic copper toxicity in dairy cows: A practical approach. N. Z. Vet. J. 62, 167-170.
Northey, S., Mohr, S., Mudd, G., Weng, Z. & Giurcom, Y.D. (2014). Modelling future copper ore grade decline based on a detailed assessment of copper resources and mining. Resour. Conserv. Recy. 83, 190–201.
Ogra, Y. & Suzuki, K.T. (1998). Targeting of tetrathiomolybdate on the copper accumulating in the liver
of LEC rats. J. Inorg. Biochem. 70, 1, 49-55.
Rosa1, F.B., Rubin, M.I.B., Martins,
T.B., Gomes, D.C. & Lemos, R.A.A. (2016). Hepatogenous chronic copper toxicosis associated with grazing Brachiariadecumbens in a goat. Braz. J. Vet. Pathol. 9, 3, 113-117.
Reed, E.,  Lutsenko, S. & Bandmann, O. (2018). Animal models of
Wilson disease. J. Neurochem. 146,
4.
Sarath, K.J. (2014). Chronic Copper Poisoning in Sheep: Liver Injury. J. Trace. Elem. Anal., 3, 1, 1-22.
Sharma, S.K., Sehkon, N.S. & Deswal, S.J. (2009). Transport and Fate of Copper in Soils. Int. J. Environ. Sci.
Eng. 1, 1.
Shlosberg, A., Egyed, M.N. & Huri, J. (1978). Acute copper poisoning in a herd of goats. Refuah. Vet. 35, 15.
Sivertsen, T. & Lovberg, K.E. (2014). Seasonal and individual variation in hepatic copper concentrations in a flock of Norwegian Dala sheep.
Small. Ruminant. Res. 116, 1, 57–
65.
Smith BP. Large Animal Internal Medicine. (2015). Elsevier
Saunders. 5th ed. PP: 837-840.
Solaiman, S.G., Maloney, M.A. & Qureshi, M.A. (2001). Effects of high copper supplements on performance, health, plasma copper and enzymes in goats. Small. Ruminant. Res. 41, 127–139.
Soli, N.E. & Nafstad, I. (1978). Effects of daily oral administration of copper to goats. Acta. Vet. Scand. 19, 561–568.
Soli, N.E. (1980). Chronic copper poisoning in sheep. Acta.
Pharmacol. Toxicol. 32, 75-77.
Spears, J.W. (2011). Genetics and animal species affect copper requirements and susceptibility to copper toxicosis. Salt Institute Newsletter.
Tessman, R.K., Lakritz, J., Tyler J.W.,
Casteel, S.W., Williams, J.E. & Dew, R.K. (2000). Sensitivity and specificity of serum copper determination for detection of copper deficiency in feeder calves. J. Am. Vet. Med. A. 218, 756-760.
Villares, R., Puente, X. & Carballeira,
A. (2002). Seasonal variation and background levels of heavy metals in two green seaweeds. Environ. Pollut. 119, 79 – 90.
Vincent B. Farming Meat Goats. 2nd  ed. (2018). Clayton South,
Australia.
Villar, D., Carson, TL. & Janke, B.H. (2002). Retrospective Study of chronic copper poisoning in Sheep. Vet. J. 18, 53-60. 
Wilkins, D.A. (1978).The measurement of tolerance to edaphic factors by means of root growth. New. Phytolo. 80, 623 – 633.
Xu, R., Jiang, Y.F., Zhang, Y.H. & Yang, X. (2018).The optimal threshold of serum ceruloplasmin in the diagnosis of Wilson’s disease: A large hospital-based study. Plos. One. 13, 1, e0190887.
 
Iranian Journal of Ruminants Health Research
Volume 2, Issue 2
November 2017
Pages 41-57

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